Click, it will get bigger, but I don't know how helpful that will be.
The Rossmann Fold. I have utterly no idea what that is. Well, I mean, obviously this is a biomolecule. If this is any help, Wikipedia says:
An example of the Rossmann fold, a structural domain of a decarboxylase enzyme from the bacterium Staphylococcus epidermidis (PDB ID 1G5Q) with a bound flavin mononucleotide cofactor.
I was just surfing around to try to learn something about ATP. Which of course means I was also learning something about ADP -- they're like Medes and Persians, they're like Picts and Scots, they're like Rosenkrantz and Guildenstern. It's impossible to get involved with one molecule without finding yourself equally immersed in the other.
Let me wax profoundly ignorant here. ATP and ADP are the molecules which living things (on this planet, anyway) use to store and distribute and liberate electromechanical energy. When you have some kind of dysfunction with your ATP and your ADP, you are in a world of shit. Make a will, if there's time and you're still conscious.
About 20 inches deep into the ATP article, there was this image of the Rossmann Fold. I haven't a clue what the Rossmann Fold has to do with ATP or ADP. I thought it was very pretty, so I filched it for the blog.
Klar? Perfekt? Any questions? Yes, this will be on the midterm.
Any answers? They would be very deeply appreciated.
2 comments:
The Rossmann fold is a type of protein domain responsible for binding a molecule called NAD (Nicotinamid Adenine Dinucleotide) or FMN (Flavin Mono Nucleotide) which is a cofactor for oxidoreductive reactions in metabolism. In the Citric Cycle, which is the aerobic pathway for forming ATP from ADP, by oxidising sugars, many intermediate reactions are catalysed by enzymes that carry a Rossmann Fold.
Hmmm, somehow I don't feel the instinct to brutally enforce the First Rule of Vleeptron: No anonymous driveby comments.
Why on earth this sentient wants to wear a Cape of Invisibility while she/he explains the Rossmann Fold to a blog which specializes in Bright, Shiny, Colorful Objects seems a bit of a mystery. To paraphrase the president of the USA: There should be limits to shyness.
WHO ARE YOU???? How do you know about this hyperobscure structure in proteins? What do you do for a living? Or are you still in school? Where?
(Some readers have kids and would appreciate a clue about which colleges and universities hose up the Smart Kids. You sound like maybe MIT or Stanford or Johns Hopkins. This doesn't sound like the Community College of Southeastern Delaware.)
Is the RF the actual mechanism of this catalysis? By what factor does the presence of proteins with the RF increase the manufacture of new molecules?
More stuff! Tell us more stuff! (Try to use Small Words.)
And finally, Masked Molecular Biologist -- what's your opinion on Folding_at_Home ? Is it blossoming into an important bio-technology? Is it the Future? Do you Fold on your computer? Got Stats? Are you an Overclocker? Do you belong to a Folding team?
THANKS for the Comment! You've really classed up Vleeptron! I'll post more Bright, Shiny, Colorful Objects, and please drop in again to tell us what the heck they are!
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